SNAP-8
For Research Use Only | Not for Human or Veterinary Use
Description:
SNAP-8 (Acetyl Octapeptide-3) is a synthetic acetylated octapeptide designed as an extended analogue of Acetyl Hexapeptide-8 (Argireline). In preclinical laboratory research, SNAP-8 is investigated for its interaction with the SNARE complex, specifically targeting the N-terminal domain of SNAP-25 (Synaptosomal-Associated Protein, 25 kDa), a key component of the vesicular membrane fusion machinery responsible for neurotransmitter exocytosis. The peptide’s eight-amino acid sequence with N-terminal acetylation competitively modulates SNARE complex assembly in a concentration-dependent manner, making it a research tool for studying synaptic vesicle fusion, neuromuscular signaling, and exocytosis-related pathways.
Scientific Specifications:
- Peptide Name: SNAP-8 (Acetyl Octapeptide-3)
- Type: Synthetic Acetylated Octapeptide (SNARE Modulator)
- Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂
- Molecular Formula: C₄₂H₇₂N₁₆O₁₅S
- Molecular Weight: ~1075.18 g/mol
- CAS Number: 868844-74-0
- PubChem CID: 71587832
- Form: Lyophilized powder
- Storage: Store dry in a cool, dark environment (2°C to 8°C)
Research Context:
SNAP-8 is commonly studied for its potential effects on:
- SNARE complex assembly modulation and SNAP-25 competitive binding interactions
- Synaptic vesicle fusion dynamics and neurotransmitter exocytosis regulation
- Neuromuscular junction signaling and acetylcholine release pathway modulation
- Comparative structure-activity relationships with Acetyl Hexapeptide-8 (Argireline)
- Concentration-dependent effects on membrane fusion protein complex formation
- Dermal fibroblast and keratinocyte signaling in skin biology research models
Intended Use:
This product is intended strictly for laboratory research applications only by qualified scientific personnel. It is not approved for human or animal consumption, and may not be used in foods, drugs, supplements, cosmetics, or diagnostics.
Legal Disclaimer:
The statements provided and this compound have not been evaluated by the U.S. Food and Drug Administration. No claims are made regarding diagnosis, treatment, or prevention of any disease. Use is restricted to qualified researchers operating in certified laboratory environments.
Terms of Sale:
By purchasing this product, the buyer affirms they are a qualified researcher or institutional purchaser, fully responsible for proper handling, storage, and legal compliance.
