THYMOSIN ALPHA-1
For Research Use Only | Not for Human or Veterinary Use
Description:
Thymosin Alpha-1 (Tα1, Thymalfasin) is a synthetic 28-amino acid peptide corresponding to the naturally occurring thymic peptide derived from proteolytic cleavage of prothymosin alpha. In preclinical laboratory research, Thymosin Alpha-1 is extensively investigated for its immunomodulatory properties, including enhancement of T-cell maturation, dendritic cell activation, and toll-like receptor (TLR) signaling. The N-terminally acetylated peptide is produced endogenously in thymic epithelial cells and is released during T-cell development, making it a central research tool in immunology, infectious disease biology, and immune checkpoint modulation studies.
Scientific Specifications:
- Peptide Name: Thymosin Alpha-1 (Tα1 / Thymalfasin)
- Type: Synthetic 28-Amino Acid Immunomodulatory Peptide
- Sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn
- Molecular Formula: C₁₂₉H₂₁₅N₃₃O₅₅
- Molecular Weight: 3108.3 g/mol
- CAS Number: 62304-98-7
- PubChem CID: 16130571
- Form: Lyophilized powder
- Storage: Store dry in a cool, dark environment (2°C to 8°C)
Research Context:
Thymosin Alpha-1 is commonly studied for its potential effects on:
- T-cell differentiation, maturation, and CD4+/CD8+ subset modulation in thymic models
- Dendritic cell activation and antigen presentation efficiency via TLR9 signaling
- Toll-like receptor (TLR2, TLR9) agonism and innate immune response amplification
- Natural killer (NK) cell cytotoxicity enhancement and immunosurveillance pathways
- Immune checkpoint interactions and T-cell exhaustion reversal in chronic infection models
- Prothymosin alpha processing and thymic peptide biology in immune ontogeny research
Intended Use:
This product is intended strictly for laboratory research applications only by qualified scientific personnel. It is not approved for human or animal consumption, and may not be used in foods, drugs, supplements, cosmetics, or diagnostics.
Legal Disclaimer:
The statements provided and this compound have not been evaluated by the U.S. Food and Drug Administration. No claims are made regarding diagnosis, treatment, or prevention of any disease. Use is restricted to qualified researchers operating in certified laboratory environments.
Terms of Sale:
By purchasing this product, the buyer affirms they are a qualified researcher or institutional purchaser, fully responsible for proper handling, storage, and legal compliance.
