MOTS-C
For Research Use Only | Not for Human or Veterinary Use
Description:
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a mitochondria-derived peptide (MDP) encoded within the mitochondrial 12S rRNA gene. In preclinical laboratory research, MOTS-c has been extensively investigated for its role as a mitochondrial-encoded signaling molecule that regulates metabolic homeostasis, AMPK activation, and folate-methionine cycle dynamics. The peptide’s unique origin as a mitochondrial genome-encoded bioactive factor distinguishes it from nuclear-encoded peptides and positions it as a key research tool for studying retrograde mitochondrial signaling, cellular energy sensing, and metabolic stress responses.
Scientific Specifications:
- Peptide Name: MOTS-c (Mitochondrial ORF of the 12S rRNA Type-c)
- Type: Mitochondria-Derived Peptide (MDP)
- Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR)
- Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
- Molecular Weight: ~2174.6 g/mol
- CAS Number: 1627580-64-6
- PubChem CID: 121231475
- Form: Lyophilized powder
- Storage: Store dry in a cool, dark environment (2°C to 8°C)
Research Context:
MOTS-c is commonly studied for its potential effects on:
- AMPK activation and downstream metabolic pathway regulation in cellular energy sensing
- Folate-methionine cycle modulation and one-carbon metabolism dynamics
- Mitochondrial retrograde signaling and nuclear gene expression regulation
- Glucose uptake and insulin sensitivity pathways in skeletal muscle models
- Cellular stress resistance and exercise-mimetic signaling in aging research models
- Mitochondria-derived peptide biology and inter-organelle communication
Intended Use:
This product is intended strictly for laboratory research applications only by qualified scientific personnel. It is not approved for human or animal consumption, and may not be used in foods, drugs, supplements, cosmetics, or diagnostics.
Legal Disclaimer:
The statements provided and this compound have not been evaluated by the U.S. Food and Drug Administration. No claims are made regarding diagnosis, treatment, or prevention of any disease. Use is restricted to qualified researchers operating in certified laboratory environments.
Terms of Sale:
By purchasing this product, the buyer affirms they are a qualified researcher or institutional purchaser, fully responsible for proper handling, storage, and legal compliance.
