IGF-1 LR3
For Research Use Only | Not for Human or Veterinary Use
Description:
IGF-1 LR3 is a synthetic 83-amino-acid analogue of human insulin-like growth factor 1, featuring enhanced potency and metabolic stability compared to native IGF-1. This compound contains an arginine substitution at position 3 (Arg³) and a 13-amino-acid N-terminal extension, resulting in reduced IGFBP (insulin-like growth factor binding protein) affinity and approximately 3-fold enhanced potency. The extended half-life of 20-30 hours enables sustained IGF-1 receptor signaling in experimental models, making it suitable for research into cell proliferation, anabolic signaling, body composition, and metabolic regulation.
Scientific Specifications:
- Compound Name: IGF-1 LR3 (Long-Acting IGF-1 Analogue)
- Type: Synthetic IGF-1 Analogue
- Amino Acid Count: 83 amino acids
- Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
- Molecular Weight: ~9117.5 g/mol
- CAS Number: 946870-92-4
- Key Features: Arg³ substitution + 13aa N-terminal extension; 3x potency of native IGF-1; half-life 20-30 hours; reduced IGFBP affinity
- Form: Lyophilized powder
Research Context:
IGF-1 LR3 is commonly studied for its potential effects on:
- IGF-1 receptor activation and PI3K/Akt signaling cascade
- MAPK/ERK pathway modulation and cell proliferation enhancement
- Body composition modulation and anabolic signaling in experimental models
- Reduced IGFBP binding and enhanced systemic bioavailability compared to native IGF-1
- Cell culture proliferation, differentiation, and survival assays
- Metabolic regulation and glucose uptake mechanisms in tissue models
Intended Use:
This product is intended strictly for laboratory research applications only by qualified scientific personnel. It is not approved for human or animal consumption, and may not be used in foods, drugs, supplements, cosmetics, or diagnostics.
Legal Disclaimer:
The statements provided and this compound have not been evaluated by the U.S. Food and Drug Administration. No claims are made regarding diagnosis, treatment, or prevention of any disease. Use is restricted to qualified researchers operating in certified laboratory environments.
Terms of Sale:
By purchasing this product, the buyer affirms they are a qualified researcher or institutional purchaser, fully responsible for proper handling, storage, and legal compliance.
