MELANOTAN I

For Research Use Only | Not for Human or Veterinary Use

Description:
Melanotan I (afamelanotide) is a synthetic linear tridecapeptide analogue of alpha-melanocyte-stimulating hormone (α-MSH), developed as a superpotent and enzymatically stable MC1R agonist. In preclinical laboratory research, Melanotan I has been investigated for its high selectivity at the melanocortin 1 receptor (MC1R) and its role in melanogenesis stimulation, eumelanin biosynthesis, and photoprotective signaling pathways. The [Nle⁴, D-Phe⁷] substitutions in the native α-MSH backbone confer significantly enhanced receptor binding affinity and resistance to enzymatic degradation, making it a key research tool in pigmentation biology and melanocortin receptor pharmacology.

Scientific Specifications:

• Peptide Name: Melanotan I (Afamelanotide)
• Type: Synthetic Linear Tridecapeptide (α-MSH Analogue)
• Sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂
• Molecular Formula: C₇₈H₁₁₁N₂₁O₁₉
• Molecular Weight: ~1646.85 g/mol
• CAS Number: 75921-69-6
• PubChem CID: 16155012
• Form: Lyophilized powder
• Storage: Store dry in a cool, dark environment (2°C to 8°C)

Research Context:
Melanotan I is commonly studied for its potential effects on:

• MC1R-selective agonism and melanocortin receptor binding kinetics
• Eumelanin biosynthesis and melanogenesis induction in melanocyte cultures
• UV-induced DNA damage protection and photoprotective signaling mechanisms
• Tyrosinase activity modulation and melanin biosynthetic pathway regulation
• Structure-activity relationships of [Nle⁴, D-Phe⁷]-substituted α-MSH analogues
• Skin pigmentation biology and keratinocyte-melanocyte paracrine interactions

Intended Use:
This product is intended strictly for laboratory research applications only by qualified scientific personnel. It is not approved for human or animal consumption, and may not be used in foods, drugs, supplements, cosmetics, or diagnostics.

Legal Disclaimer:
The statements provided and this compound have not been evaluated by the U.S. Food and Drug Administration. No claims are made regarding diagnosis, treatment, or prevention of any disease. Use is restricted to qualified researchers operating in certified laboratory environments.

Terms of Sale:
By purchasing this product, the buyer affirms they are a qualified researcher or institutional purchaser, fully responsible for proper handling, storage, and legal compliance.