SEMAX

For Research Use Only | Not for Human or Veterinary Use

Description:
Semax is a synthetic heptapeptide analogue of the adrenocorticotropic hormone (ACTH) fragment 4–7, extended at the C-terminus with a Pro-Gly-Pro stabilizing motif. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Semax is investigated in preclinical laboratory research for its nootropic properties, neurotrophic factor upregulation, and neuroprotective signaling activity. The Pro-Gly-Pro extension confers enhanced resistance to aminopeptidase degradation compared to the native ACTH(4–7) fragment, while the compound retains melanocortin receptor-independent neurotrophic activity, making it a widely used research tool in cognitive neuroscience, neuroplasticity, and cerebrovascular research models.

Scientific Specifications:

• Peptide Name: Semax (ACTH 4–10 Analogue)
• Type: Synthetic Heptapeptide (Nootropic ACTH Fragment Analogue)
• Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
• Molecular Formula: C₃₇H₅₁N₉O₁₀S
• Molecular Weight: 813.92 g/mol
• CAS Number: 80714-61-0
• PubChem CID: 9811102
• Form: Lyophilized powder
• Storage: Store dry in a cool, dark environment (2°C to 8°C)

Research Context:
Semax is commonly studied for its potential effects on:

• Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) expression upregulation
• Cognitive performance, learning acquisition, and memory consolidation in behavioral paradigms
• Cerebrovascular protection and gene expression modulation in focal ischemia models
• Dopaminergic and serotonergic neurotransmitter system modulation in brain regions
• Immune-related gene expression and chemokine/immunoglobulin pathway regulation
• Neuroplasticity mechanisms and synaptic remodeling in hippocampal and cortical models

Intended Use:
This product is intended strictly for laboratory research applications only by qualified scientific personnel. It is not approved for human or animal consumption, and may not be used in foods, drugs, supplements, cosmetics, or diagnostics.

Legal Disclaimer:
The statements provided and this compound have not been evaluated by the U.S. Food and Drug Administration. No claims are made regarding diagnosis, treatment, or prevention of any disease. Use is restricted to qualified researchers operating in certified laboratory environments.

Terms of Sale:
By purchasing this product, the buyer affirms they are a qualified researcher or institutional purchaser, fully responsible for proper handling, storage, and legal compliance.