TB-500
For Research Use Only | Not for Human or Veterinary Use
Description:
TB-500 is a synthetic peptide corresponding to the full 43-amino acid sequence of Thymosin Beta-4 (Tβ4), an endogenous actin-sequestering protein encoded by the TMSB4X gene. In preclinical laboratory research, TB-500 is extensively investigated for its role in actin polymerization regulation, cell migration, angiogenesis, and tissue repair signaling. The active region of Thymosin Beta-4, centered around the actin-binding domain (residues 17–23: LKKTETQ), is responsible for G-actin sequestration and cytoskeletal dynamics modulation. TB-500 serves as a widely used research tool in wound healing biology, inflammatory signaling, cardiovascular repair models, and musculoskeletal regeneration studies.
Scientific Specifications:
- Peptide Name: TB-500 (Thymosin Beta-4)
- Type: Synthetic 43-Amino Acid Peptide (Actin-Sequestering Protein)
- Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
- Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S
- Molecular Weight: 4963.44 g/mol
- CAS Number: 77591-33-4
- PubChem CID: 16132341
- Form: Lyophilized powder
- Storage: Store dry in a cool, dark environment (2°C to 8°C)
Research Context:
TB-500 is commonly studied for its potential effects on:
- G-actin sequestration and cytoskeletal dynamics regulation via the LKKTETQ binding domain
- Cell migration promotion and lamellipodium formation in wound healing models
- Angiogenesis stimulation and endothelial cell tube formation in vascular research
- Anti-inflammatory signaling and NF-κB pathway modulation in tissue injury models
- Cardiac repair and cardiomyocyte survival signaling in ischemia-reperfusion paradigms
- Hair follicle stem cell activation and dermal regeneration in skin biology models
Intended Use:
This product is intended strictly for laboratory research applications only by qualified scientific personnel. It is not approved for human or animal consumption, and may not be used in foods, drugs, supplements, cosmetics, or diagnostics.
Legal Disclaimer:
The statements provided and this compound have not been evaluated by the U.S. Food and Drug Administration. No claims are made regarding diagnosis, treatment, or prevention of any disease. Use is restricted to qualified researchers operating in certified laboratory environments.
Terms of Sale:
By purchasing this product, the buyer affirms they are a qualified researcher or institutional purchaser, fully responsible for proper handling, storage, and legal compliance.
